Mayer supported herself as an artist in Manhattan in the 1950s and in 1960 exhibited as Joyce Harris, with Horizon Gallery in Greenwich Village and with the National Arts Club in 1966. In 1969 she became Joyce Harris Mayer. She and her husband Bernard welcomed their son Robert into the world two years later.
In 1974 Mayer had one-person exhibitions at the Brunswick Media Center and the Greenwich Art Society in Connecticut, and she participated in an exhibition in the Bruce Museum. She was commissioned to design the logo for Archeology Associates of Greenwich.
In 1978 Art International exhibited several of her Great Mother images along with sculpture by Mary Frank and Lucy Lippard placed her Great Mother images in an exhibition at the Hurlbutt...